MLBComputerPicksMLB Computer Picks: Best Bets for September 24, 2026
Published · Auto-generated from the model
Today's top MLB computer picks for Thursday, September 24, 2026, ranked by the size of the model's edge.
1. St. Louis Cardinals at Pittsburgh Pirates — STL +1.5 Strong
The market opened at -1.5 on the home side, but our projected margin is far enough from that number to flag value. The recommendation is STL +1.5, an edge of about 1.6 runs in our favor. For the over/under, our pace-adjusted projection lands near 8.1 runs against the posted 3.5. That points to the Over 3.5, with about 4.6 runs of over edge.
Model confidence 85% · projected STL 4 – PIT 4 · full preview →
2. Chicago White Sox at Kansas City Royals — KC +6.5 Strong
Where the book sits at 6.5 on KC, our simulation disagrees by enough to make this a live run line play. The recommendation is KC +6.5, an edge of about 7.7 runs in our favor. Totals-wise, the simulation expects roughly 8.4 runs while the book has hung 12.5. That points to the Under 12.5, with about 4.1 runs of under edge.
Model confidence 85% · projected CWS 4 – KC 5 · full preview →
3. Miami Marlins at Chicago Cubs — MIA +1.5 Strong
The market opened at -1.5 on the home side, but our projected margin is far enough from that number to flag value. The recommendation is MIA +1.5, an edge of about 0.7 runs in our favor. On the total, the model projects around 8.1 combined runs versus a market number of 6.5. That points to the Over 6.5, with about 1.6 runs of over edge.
Model confidence 85% · projected MIA 4 – CHC 4 · full preview →
4. Cleveland Guardians at Boston Red Sox — CLE +1.5 Strong
The market opened at -1.5 on the home side, but our projected margin is far enough from that number to flag value. The recommendation is CLE +1.5, an edge of about 1.5 runs in our favor. On the total, the model projects around 8.7 combined runs versus a market number of 6.5. That points to the Over 6.5, with about 2.2 runs of over edge.
Model confidence 85% · projected CLE 4 – BOS 4 · full preview →
5. Tampa Bay Rays at New York Yankees — TB +1.5 Strong
The market opened at -1.5 on the home side, but our projected margin is far enough from that number to flag value. The recommendation is TB +1.5, an edge of about 0.8 runs in our favor. Totals-wise, the simulation expects roughly 8.5 runs while the book has hung 6.5. That points to the Over 6.5, with about 2.0 runs of over edge.
Model confidence 85% · projected TB 4 – NYY 5 · full preview →